Research

Collaborative Research

During the evolution of TERC, collaborative research has progressed in osteochondral, cardiovascular and other areas of tissue engineering. A variety of joint research projects were initiated related to biomaterials, tissue cultivation, cell screening, biomechanics, imaging, mathematical modeling, and functional studies. Collaborative efforts were also initiated with another P41 center – BioMEMs, and with many other institutions including Children’s Hospital and Beth Israel Hospital in Boston. Interactions between TERC and outside institutions have expanded every year, and we now have a strong network of collaborators.

We have continued to build upon the current collaborations and evaluate potential collaborations on a case by case basis. One strategy that we have found efficient is to start new collaborations more as a service function. Upon evaluating a first set of materials, cells or bioreactors provided by TERC, the team can work with the interested party to determine a collaboration path based on the outcome of the initial study, including joint proposals, and funding provided directly by the outside party.

A group of collaborative projects are highlighted below:

Multifunctional Tropoelastin-Silk Biomaterial Systems, NIH
Collaborator: Anthony Weiss, University of Sydney

Novel Strategies in Bladder Tissue Engineering: Stem Cells and Silk Biomaterials, NIH
Collaborator: Joshua Mauney & Carlos Estrada, Boston Children's Hospital; Harvard Medical School

Engineering vascularized bone from human IPS cells for craniofacial regeneration, NYSCF
Collaborator: Darja Marolt, New York Stem Cell Foundation

Biomechanical regulation of myocardial differentiation of mesodermal progenitors, German Science Foundation
Collaborator: Wolfram Zimmermann, Stanford University

Soft Tissue Regeneration, DoD
Collaborator: Kacey Marra & Peter Rubin, University of Pittsburgh; James Yoo, Wake Forest University

Models to predict protein biomaterial performance, NIH
Collaborator: Markus Buehler, MIT; Joyce Wong. Boston University

Models to Predict Traumatic Brain Injury, NIH
Collaborator: Michael Whalen, Massachusetts General Hospital