David L. Kaplan
Professor, Department of Chemical and Biological Engineering
Chair and Professor, Department of Biomedical Engineering
Director, Bioengineering and Biotechnology Center

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Selected Publications:

Mapping domain structures in silks from insects and spiders. E. Bini, D. Knight, D. L. Kaplan. J. Molecular Biology. 335:27-40 (2004).

Bone tissue engineering using human mesenchymal stem cells; effects of scaffold material and medium flow. Meinel, L., V. Karageorgiou, R. Fajardo, B. Snyder, V. Shinde-Patil, L. Zichner, D. L. Kaplan, R. Langer, G. Vunjak-Novakovic. Annals Biomed. Eng. 32:112-122 (2004).

Matrix-mediated retention of osteogenic differentiation potential by human adult bone marrow stromal cells during ex vivo expansion. J. R. Mauney, D. L. Kaplan, V. Volloch. Biomaterials 25:3233-3243 (2004).

Self-assembly and biocatlysis in the synthesis of nanostructured polymers and polymer-ceramic composites. C. Ford, V. John, G. McPherson, J. He, J. Akkara, D. L. Kaplan, A. Bose. In press (2004).

Osteogenic Differentiation of Human Bone Marrow Stromal Cells on Partially Demineralized Bone Scaffolds In Vitro. Mauney JR, Blumberg J, Pirun M, Volloch V, Vunjak-Novakovic G, Kaplan DL Tissue Engineering, 10:81-92 (2004).

Inflammatory responses to silk films in vitro and in vivo. L. Meinel, S. Hofmann, V. Karageorgiou, C. Kirker-Head, J. McCool, G. Gronwicz, L. Zichner, R. Langer, G. Vunjak-Novakovic. D. L. Kaplan. Biomaterials. 26:147-155 (2004).

Nanoscale surface patterning of enzyme catalyzed polymeric conducting wires. P. Xu, D. L. Kaplan. Advanced Materials, 16:628-632(2004)

Porous 3D scaffolds from regenerated silk fibroin. R. Nazarov, H.-J. Jin, D. L. Kaplan. Biomacromolecules. 5:718-726 (2004).

Biomaterials films of Bombyx mori silk with poly(ethylene oxide). H.-J. Jin, J. Park, U.-J. Kim, R. Valluzzi, P. Cebe, D. L. Kaplan. Biomacromolecules. 5:711-717 (2004).

Structure and properties of silk hydrogels. U.-J. Kim, J. Park, C. Li, H.-J. Jin, R. Valluzzi, D. L. Kaplan. Biomacromolecules. 5:786-792 (2004).

Microbial polysaccharides. T. Harrah, B. Panilaitis, D. L. Kaplan. In Microbial Polysaccharides, E. Rosenberg, Ed. (2004).

Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. J. R. Mauney, S. Sjostorm, J. Blumberg, R. Horan, J. P. O'Leary, G. Vunjak-Novakovic, V. Volloch, D. L. Kaplan. Calcified Tissue International, 74:458-468 (2004)

Bioreactors for orthopaedic tissue engineering. G. Vunjak-Novakovic, B. Obradovic, H. Madry, G. Altman, D. L. Kaplan. In Orthopaedic Tissue Engineering: Basic Science and Practice (Ed. A. I. Caplan and V. Goldberg), Marcel Dekker Inc., New York, pp. 123-147 (2004).

Impact of matrix trafficking by human fibroblasts. L. Abraham, J. Vorasi, D. L. Kaplan. J. Biomedical Materials Research, 70A:39-48 (2004).

Tissue engineering of ligaments. G. Vunjak-Novakovic, G. Altman, R. Horan, D. L. Kaplan. Annual Review of Biomedical Engineering. 6:14.1-14.26 (2004).

Tissue engineering of osteochondral plugs using human mesenchymal stem cells and silk scaffolds. Meinel, L., V. Karageorgiou, S. Hoffmann, R. Fajardo, B. Snyder, C. Li, L. Zichner, R. Langer, G. Vunjak-Novakovic, D. L. Kaplan. Chemical Industry 58:68-69 (2004).

Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds. L. Meinel, S. Hoffmann, V. Karageorgiou, L. Zichner, R. Langer, G. Vunjak-Novakovic, D. L. Kaplan. Biotechnology and Bioengineering. 88:379-391 (2004).

Human bone marrow stromal cell responses on electrospun silk fibroin mats. H. J. Jin, J. Chen, V. Kargeorgiou, G. H. Altman, D. L. Kaplan. Biomaterials 25:1039-1047 (2004).

Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds. L. Meinel, V. Kargeorgiou, S. Hofmann, R. Fajardo, B. Snyder, C. Li, L. Zichner, R. Langer, G. Vunjak-Novakovic, D. L. Kaplan. J. Biomedical Materials Research, 71A:25-34 (2004).

Lessons from seashells: mineralized silica via protein templating, C. Wong Po Foo, J. Huang, D. L. Kaplan, Trends in Biotechnology 22:577-585 (2004).

Vitamin C functionalized poly(methyl methacrylate) for free radical scavenging. A. Singh, D. L. Kaplan. J. Macromolecular Science – Pure and Appl. Chemistry A41:1377-1386 (2004).

Horseradish peroxidase catalyzed polymerization of tyrosine derivatives for nanoscale surface patterning. P. Xu, D. L. Kaplan. J. Macromolecular Science – Pure and Appl. Chemistry A41:1437-1446 (2004).

Emulsan quantitation by Nile Red quenching fluorescence assay, G. R. Castro, B. K. Larson, B. Panilaitis, D. L. Kaplan, Applied Microbiology and Biotechnology, published online (2004).

Growth factor induced fibroblast differentiation from human bone marrow stromal cells in vitro. J. E. Moreau, J. Chen, D. Bramono, V. Volloch, H. Chernoff, G. Vunjak-Novakovic, J. Richmond, D. L. Kaplan, G. H. Altman. J. Orthopaedic Research, 23: 164-174 (2005)

Mechanical properties of electrospun silk fibers. M. Wang, H.J. Jin, D. L. Kaplan, G. C. Rutledge. Macromolecules, 37:6856-6864 (2004).

Matrix metalloproteinases and their clinical applications in orthopaedics. D. S. Bramono, D. L. Kaplan, J. C. Richmond, P. P. Weitzel, G. H. Altman. Clinical Orthopaedics. 428: 272-285 (2004).

Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells. V. Karageorgiou, L. Meinel, S. Hofmann, A. Malhotra, V. Volloch, D. L. Kaplan. J. Biomedical Materials Research, 71A:528-537 (2004).

In vitro degradation of silk fibroin. R. L. Horan, K. Antle, A. L. Collette, Y. Wang, J. Huang, J. E. Moreau, V. Volloch, D. L. Kaplan, G. H. Altman. Biomaterials 26:3385-3393 (2005).

In vitro and in vivo evaluation of differentially mineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering. J. Mauney, C. Jaquiery, V. Volloch, I. Martin, D. L. Kaplan. Biomaterials, in press (2005).

Three dimensional aqueous-derived biomaterial scaffolds from silk fibroin. U.J. Kim, J. Park, H. J. Kim, M. Wada, D. L. Kaplan. Biomaterials, in press (2005).

Tissue engineering of bone, S. Hofmann, D. L. Kaplan, G. Vunjak-Novakovic, L. Meinel. In Specialized cell cultures for tissue engineering, Eds. G. Vunjak-Novakovic, I. Freshney, J. Wiley, in press (2005).

Bioreactor cultivation of osteochondral tissues. Vunjak-Novakovic, G., L. Meinel, G. Altman, L. E. Freed, D. L. Kaplan. Orthodontics and Craniofacial Research, in press (2005).

Influence of macroporous protein scaffolds on bone tissue engineering from bone marrow stem cells. H. J. Kim, U-J. Kim, G. Vunjak-Novakovic, B-H. Min, D. L. Kaplan. Biomaterials, in press (2005).

Emulsan quantitation by Nile Red quenching fluorescence assay, G. R. Castro, B. K. Larson, B. Panilaitis, D. L. Kaplan, Applied Microbiology and Biotechnology, in press (2005).

Biopolymer scaffolds for tissue engineering. J. Velma, D. L. Kaplan. In Tissue Engineering, Advances in Biochemical Engineering/Biotechnology, Edited by K. Lee, D. L. Kaplan, Spring-Verlag, in press (2005).

The role of adult mesenchymal stem cells in bone tissue engineering applications: current status and future prospects. V. Karagerogiou, D. L. Kaplan. Tissue Eng. in press (2005).