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Science and Technology
Center, Room 276A
Tufts University
4 Colby Street
Medford, MA 02155

Tel: 617.627.0831
Fax: 617.627.3991
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Emmanuel (Manolis) S. Tzanakakis
Associate Professor, Department of Chemical and Biological Engineering


2002 Post-doctoral Fellow, Diabetes Center, University of California-San Francisco, CA
2001 Post-doctoral Fellow, Stem Cell Institute, University of Minnesota, MN
2001 Ph.D., Chemical Engineering, University of Minnesota, MN
1995 Dipl., Chemical Engineering, Aristotle University of Thessaloniki, Greece

Research Interests

  • Stem cell engineering
  • Stem cell bioprocessing
  • Multiscale models of stem cell ensembles

Pluripotent stem cells self-renew extensively and give rise to multiple cell types of therapeutic significance. Our laboratory investigates the molecular determinants of stem cell commitment along particular lineages, mainly to heart muscle and pancreatic endocrine insulin-producing cells. Additionally, our efforts concentrate on the scalable expansion and differentiation, which are prerequisites for the realization of stem cell-based applications envisioned in regenerative medicine and tissue engineering. Lastly, experiments are coupled to multiscale stochastic models for describing, predicting and optimizing the phenotypic outcome in stem cell populations under various contexts in vitro and in vivo.

Selected Honors and Awards

  • James D. Watson Investigator Award, New York State Office of Science, Technology and Academic Research (NYSTAR) (2006 – 2008)
  • Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2003 – 2005)

Selected Courses Taught

  • Applied Numerical Methods for Chemical and Biological Engineering (ChBE)
  • Fundamentals of Chemical Engineering (ChBE)
  • Chemical Plant Design (ChBE)
  • Biological Transport & Kinetics (BME/ChBE)
  • Biosystems Engineering (BME/ChBE)
  • Fluid Mechanics (ChBE)