Tissue Engineering

The group takes a multi-fold approach to the challenges of tissue regeneration. Traditional biochemical factors are utilized to direct stem cell and tissue outcomes in selective (temporal, regional, interfacial) approaches. In addition, a major focus is on biophysical factors (membrane potential Vmem, external electric fields, mechanical forces) on cell and tissue outcomes. The orchestrated suite of inputs to cell and tissue functions is considered towards desired fundamental goals, for building quantitative metabolic models of tissue functions and regeneration in vitro, and to generate useful tissue systems for in vitro study and in vivo utility. Example tissues under study: bone, cartilage, small diameter vasculature, neurological tissues, cervical, kidney, adipose, among others.

photo collage of nerve regeneration, 3-D cell culture in hydrogels, 3-D cell culture in solid scaffolds, and bone engineering