TERC Structure & Evolution

TERC 1.0 TERC 2.0 TERC 3.0
Basic Biomaterial Formulation & Characterizaton
Perfusion Bioreactor Development
Simple, Single-cell Cultures
Advanced Biomaterials (Composites, etc.)
Multi-parameter Bioreactors (simulations & scale)
Complex Functional Tissue Engineering
Improved Vascularization & Integration of Biomaterials
"Plug'n' Play" & Transitional Bioreactors
Disease Modeling Tissue Constructs

The Foundational Research of TERC has led to significant advances in biomaterials, bioreactors, tissue engineering, and disease modeling. While each individual institution within TERC has its focus (Biomaterials at Tufts University, Bioreactors at Columbia University), research integration and collaboration between the two institutions is strong and consistent across almost all phases of research. Each institution brings complementary strengths to the Center, and this has led to a synergistic effect on the research progress.

Tissue engineering and regenerative medicine continue to rely on advances at the fundamental level, while supporting clinical and industrial efforts with significant impact on human health. As we look to the future, TERC is uniquely positioned to help advance the field precisely because it maintains a core research program in the fundamentals of tissue engineering (stem cell biology, tissue biomechanics, bioreactor design, biomaterials development, integration with imaging), while pushing the field forward with preclinical studies, translation activities, development of platform technologies, and disease modeling.

Our research has spawned collaborative projects, service projects, and many other opportunities that feed into our fundamental research. As we continue to develop more complex and customized biomaterial and bioreactor systems, we initiate collaborations in new tissue types and disease states. The lessons learned are expected to further strengthen the foundational research with new demands on our systems. This research feedback loop has resulted in significant advances and new directions for the Center while maintaining solid foundational work.