Selected Publications

Key Publications

Perrone GS, Leisk GG, Lo TJ, Moreau JE, Haas DS, Papenburg BJ, et al. The use of silk-based devices for fracture fixation. Nat Commun. 2014;5.

Kluge JA, Li AB, Kahn BT, Michaud DS, Omenetto FG, Kaplan DL. Silk-based blood stabilization for diagnostics. Proceedings of the National Academy of Sciences. 2016;113:5892-7.

Tang-Schomer MD, White JD, Tien LW, Schmitt LI, Valentin TM, Graziano DJ, et al. Bioengineered functional brain-like cortical tissue. Proceedings of the National Academy of Sciences. 2014;111:13811-6.

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, et al. Robust bioengineered 3D functional human intestinal epithelium. Scientific Reports. 2015;5:13708.

Peer-reviewed manuscripts

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL. Non-invasive Assessments of Adipose Tissue Metabolism In Vitro. Annals of biomedical engineering. 2015. doi: 10.1007/s10439-015-1438-9. PubMed PMID: 26399988.

Abbott RD, Kaplan DL. Strategies for improving the physiological relevance of human engineered tissues. Trends in biotechnology. 2015;33(7):401-7. doi: 10.1016/j.tibtech.2015.04.003. PubMed PMID: 25937289; PMCID: PMC4475434.

Abbott RD, Raja WK, Wang RY, Stinson JA, Glettig DL, Burke KA, Kaplan DL. Long term perfusion system supporting adipogenesis. Methods. 2015;84:84-9. doi: 10.1016/j.ymeth.2015.03.022. PubMed PMID: 25843606; PMCID: PMC4526405.

Bai S, Han H, Huang X, Xu W, Kaplan DL, Zhu H, Lu Q. Silk scaffolds with tunable mechanical capability for cell differentiation. Acta biomaterialia. 2015;20:22-31. doi: 10.1016/j.actbio.2015.04.004. PubMed PMID: 25858557; PMCID: PMC4428940.

Bellas E, Rollins A, Moreau JE, Lo T, Quinn KP, Fourligas N, Georgakoudi I, Leisk GG, Mazan M, Thane KE, Taeymans O, Hoffman AM, Kaplan DL, Kirker-Head CA. Equine model for soft-tissue regeneration. Journal of biomedical materials research Part B, Applied biomaterials. 2015;103(6):1217-27. doi: 10.1002/jbm.b.33299. PubMed PMID: 25350377.

Bhumiratana S, Vunjak-Novakovic G. Engineering physiologically stiff and stratified human cartilage by fusing condensed mesenchymal stem cells. Methods. 2015;84:109-14. doi: 10.1016/j.ymeth.2015.03.016. PubMed PMID: 25828645; PMCID: PMC4526344.

Bova JF, da Cunha AF, Stout RW, Bhumiratana S, Alfi DM, Eisig SB, Vunjak-Novakovic G, Lopez MJ. Bupivacaine mandibular nerve block affects intraoperative blood pressure and heart rate in a Yucatan miniature swine mandibular condylectomy model: a pilot study. Journal of investigative surgery: the official journal of the Academy of Surgical Research. 2015;28(1):32-9. doi: 10.3109/08941939.2014.971207. PubMed PMID: 25394295; PMCID: PMC4479207.

Cardwell RD, Kluge JA, Thayer PS, Guelcher SA, Dahlgren LA, Kaplan DL, Goldstein AS. Static and cyclic mechanical loading of mesenchymal stem cells on elastomeric, electrospun polyurethane meshes. Journal of biomechanical engineering. 2015;137(7). doi: 10.1115/1.4030404. PubMed PMID: 25902471; PMCID: PMC4462860.

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL. Robust bioengineered 3D functional human intestinal epithelium. Scientific reports. 2015;5:13708. doi: 10.1038/srep13708. PubMed PMID: 26374193; PMCID: PMC4571649.

Chwalek K, Sood D, Cantley WL, White JD, Tang-Schomer M, Kaplan DL. Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue. J Vis Exp. 2015(105):e52970. doi: 10.3791/52970. PubMed PMID: 26555926; PMCID: PMC4692668.

Chwalek K, Tang-Schomer MD, Omenetto FG, Kaplan DL. In vitro bioengineered model of cortical brain tissue. Nat Protoc. 2015;10(9):1362-73. doi: 10.1038/nprot.2015.091. PubMed PMID: 26270395.

Coburn JM, Kaplan DL. Engineering Biomaterial-Drug Conjugates for Local and Sustained Chemotherapeutic Delivery. Bioconjugate chemistry. 2015;26(7):1212-23. doi: 10.1021/acs.bioconjchem.5b00046. PubMed PMID: 25689115.

DesRochers TM, Kimmerling EP, Jandhyala DM, El-Jouni W, Zhou J, Thorpe CM, Leong JM, Kaplan DL. Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue. Infection and immunity. 2015;83(1):28-38. doi: 10.1128/IAI.02143-14. PubMed PMID: 25312954; PMCID: PMC4288879.

DesRochers TM, Kuo IY, Kimmerling EP, Ehrlich BE, Kaplan DL. The effects of mycoplasma contamination upon the ability to form bioengineered 3D kidney cysts. PloS one. 2015;10(3):e0120097. doi: 10.1371/journal.pone.0120097. PubMed PMID: 25793639; PMCID: PMC4368695.

Domigan LJ, Andersson M, Alberti KA, Chesler M, Xu Q, Johansson J, Rising A, Kaplan DL. Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands. Insect Biochem Mol Biol. 2015;65:100-6. doi: 10.1016/j.ibmb.2015.09.001. PubMed PMID: 26365738; PMCID: PMC4628561.

Elia R, Guo J, Budijono S, Normand V, Benczedi D, Omenetto F, Kaplan DL. Encapsulation of Volatile Compounds in Silk Microparticles. J Coat Technol Res. 2015;12(4):793-9. doi: 10.1007/s11998-015-9668-1. PubMed PMID: 26568787; PMCID: PMC4640459.

Elia R, Michelson CD, Perera AL, Brunner TF, Harsono M, Leisk GG, Kugel G, Kaplan DL. Electrodeposited silk coatings for bone implants. Journal of biomedical materials research Part B, Applied biomaterials. 2015;103(8):1602-9. doi: 10.1002/jbm.b.33351. PubMed PMID: 25545462; PMCID: PMC4480203.

Eng G, Lee BW, Protas L, Gagliardi M, Brown K, Kass RS, Keller G, Robinson RB, Vunjak-Novakovic G. Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. Nature communications. 2016;7:10312. doi: 10.1038/ncomms10312. PubMed PMID: 26785135; PMCID: PMC4735644.

Gadjanski I, Vunjak-Novakovic G. Challenges in engineering osteochondral tissue grafts with hierarchical structures. Expert Opin Biol Ther. 2015;15(11):1583-99. doi: 10.1517/14712598.2015.1070825. PubMed PMID: 26195329; PMCID: PMC4628577.

Godier-Furnemont AF, Tiburcy M, Wagner E, Dewenter M, Lammle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials. 2015;60:82-91. doi: 10.1016/j.biomaterials.2015.03.055. PubMed PMID: 25985155.

Han Q, Yang P, Wu Y, Meng S, Sui L, Zhang L, Yu L, Tang Y, Jiang H, Xuan D, Kaplan DL, Kim SH, Tu Q, Chen J. Epigenetically Modified Bone Marrow Stromal Cells in Silk Scaffolds Promote Craniofacial Bone Repair and Wound Healing. Tissue engineering Part A. 2015;21(15-16):2156-65. doi: 10.1089/ten.TEA.2014.0484. PubMed PMID: 25923143; PMCID: PMC4529088.

Jose RR, Raja WK, Ibrahim AM, Koolen PG, Kim K, Abdurrob A, Kluge JA, Lin SJ, Beamer G, Kaplan DL. Rapid prototyped sutureless anastomosis device from self-curing silk bio-ink. Journal of biomedical materials research Part B, Applied biomaterials. 2015;103(7):1333-43. doi: 10.1002/jbm.b.33312. PubMed PMID: 25385518; PMCID: PMC4427544.

Kim J, O'Neill JD, Dorrello NV, Bacchetta M, Vunjak-Novakovic G. Targeted delivery of liquid microvolumes into the lung. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(37):11530-5. doi: 10.1073/pnas.1512613112. PubMed PMID: 26324893; PMCID: PMC4577144.

Lee BW, Liu B, Pluchinsky A, Kim N, Eng G, Vunjak-Novakovic G. Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue. Advanced healthcare materials. 2016. doi: 10.1002/adhm.201500956. PubMed PMID: 26865105.

Li AB, Kluge JA, Guziewicz NA, Omenetto FG, Kaplan DL. Silk-based stabilization of biomacromolecules. Journal of controlled release : official journal of the Controlled Release Society. 2015;219:416-30. doi: 10.1016/j.jconrel.2015.09.037. PubMed PMID: 26403801; PMCID: PMC4656123.

Li C, Levin M, Kaplan DL. Bioelectric modulation of macrophage polarization. Scientific reports. 2016;6:21044. doi: 10.1038/srep21044. PubMed PMID: 26869018; PMCID: PMC4751571.

Li JJ, Kim K, Roohani-Esfahani SI, Guo J, Kaplan DL, Zreiqat H. A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration. Journal of materials chemistry B, Materials for biology and medicine. 2015;3(26):5361-76. doi: 10.1039/C5TB00353A. PubMed PMID: 26167284; PMCID: PMC4494762.

Lin Y, Wang S, Chen Y, Wang Q, Burke KA, Spedden EM, Staii C, Weiss AS, Kaplan DL. Electrodeposited gels prepared from protein alloys. Nanomedicine. 2015;10(5):803-14. doi: 10.2217/nnm.14.230. PubMed PMID: 25816881; PMCID: PMC4382808.

Parsa H, Ronaldson K, Vunjak-Novakovic G. Bioengineering methods for myocardial regeneration. Advanced drug delivery reviews. 2016;96:195-202. doi: 10.1016/j.addr.2015.06.012. PubMed PMID: 26150344; PMCID: PMC4698189.

Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL. Controlled release of cytokines using silk-biomaterials for macrophage polarization. Biomaterials. 2015;73:272-83. doi: 10.1016/j.biomaterials.2015.09.027. PubMed PMID: 26421484; PMCID: PMC4605898.

Samal SK, Goranov V, Dash M, Russo A, Shelyakova T, Graziosi P, Lungaro L, Riminucci A, Uhlarz M, Banobre-Lopez M, Rivas J, Herrmannsdorfer T, Rajadas J, De Smedt S, Braeckmans K, Kaplan DL, Dediu VA. Multilayered Magnetic Gelatin Membrane Scaffolds. ACS applied materials & interfaces. 2015;7(41):23098-109. doi: 10.1021/acsami.5b06813. PubMed PMID: 26451743.

Seib FP, Coburn J, Konrad I, Klebanov N, Jones GT, Blackwood B, Charest A, Kaplan DL, Chiu B. Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo. Acta biomaterialia. 2015;20:32-8. doi: 10.1016/j.actbio.2015.04.003. PubMed PMID: 25861948; PMCID: PMC4428956.

Stoppel WL, Kaplan DL, Black LD, 3rd. Electrical and mechanical stimulation of cardiac cells and tissue constructs. Advanced drug delivery reviews. 2016;96:135-55. doi: 10.1016/j.addr.2015.07.009. PubMed PMID: 26232525; PMCID: PMC4698182.

Thurber AE, Omenetto FG, Kaplan DL. In vivo bioresponses to silk proteins. Biomaterials. 2015;71:145-57. doi: 10.1016/j.biomaterials.2015.08.039. PubMed PMID: 26322725; PMCID: PMC4573254.

Tokareva OS, Glettig DL, Abbott RD, Kaplan DL. Multifunctional spider silk polymers for gene delivery to human mesenchymal stem cells. Journal of biomedical materials research Part B, Applied biomaterials. 2015;103(7):1390-401. doi: 10.1002/jbm.b.33322. PubMed PMID: 25399785; PMCID: PMC4433878.

Zheng ZZ, Liu M, Guo SZ, Wu JB, Lu DS, Li G, Liu SS, Wang XQ, Kaplan DL. Incorporation of quantum dots in silk biomaterials for fluorescence imaging. Journal of materials chemistry B, Materials for biology and medicine. 2015;3(31):6509-19. doi: 10.1039/C5TB00326A. PubMed PMID: 26257913; PMCID: PMC4527682.