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Current group members

Ryan P. Nolan, graduate student
Ryan received his B.S. in Biomedical Engineering from Johns Hopkins University in 2003 and M.S. in Chemical Engineering from Tufts University in 2005. Since 2005 he has been working as a Process Engineer at Pfizer (formally Wyeth BioPharma). In 2007 he decided to continue his graduate studies and returned to Tufts to pursue a Ph.D. part-time. Ryan's research is focused on creating dynamic metabolic models of the cell culture processes used in the biopharmaceutical industry.

Gautham V. Sridharan, graduate student
Gautham graduated with a B.S. in Chemical Engineering from Cornell University in 2008. At Cornell, he was an undergraduate research assistant under Dr. Kelvin H. Lee, and studied the effect of translation rate on the secretion of therapeutic proteins in E.coli. Under the tutelage of Dr. Kunal Aggarwal, and Dr. Prateek Gupta, who were former graduate students in the group, he gained laboratory experience in a wide range of molecular biology techniques. Gautham has also held industry internships at Novartis, as well as Momenta Pharmaceuticals. Here, at Tufts, he is working on in vitro models for hepatic drug metabolism from dynamic metabolomic data as a tool for toxicity screening. The modeling effort in his project is in collaboration with Dr. Soha Hassoun from Computer Science.

Katherine A. Carson, graduate student
Kate Carson earned her BA at Smith College, with a double major in chemistry and physics. After graduating in 2004, Kate spent a year teaching physics and swimming at Phillips Academy in Andover, MA, before moving on to teach chemistry and physics at Dover Sherborn Regional High School in Dover, MA. She then worked at US Genomics, developing microfluidic technology for the identification of airborne pathogens through single-molecule detection of pathogenic DNA. At Tufts, Kate's research focuses on the liver, identifying signs of drug-induced stress through metabolic and microfluidic studies. Kate has a passion for education and hopes to return to teaching and curriculum development after her time at Tufts.

James K. Sims, graduate student
James grew up in Dallas, TX and came to Boston in 2005 to work on his B.S. in Chemical Engineering at Northeastern University. At Northeastern, James investigated precipitation of drug compounds in the gastrointestinal tract, and also attempted to characterize drug diffusion through intestinal mucus. He also held co-op positions at Gillette and Acceleron Pharma. After graduating from Northeastern, he took an internship at Novartis Vaccines where he produced and characterized RNA vaccines. At Tufts, he is developing an in vitro model for vascularized adipose tissue. This model will be used to study the interactions between adipocytes and endothelial cells, and also for characterizing possible therapeutics (specifically siRNA knockdown). Outside of the lab, James enjoys spending time with his dogs, playing the piano and French horn, and skiing (in the winter).

Michael C. Yi, undergraduate student
Michael has been working in the laboratory since fall of 2009, focusing on method development for metabolite analysis using liquid chromatography-mass spectrometry (LC-MS). He is a rising junior at Tufts, with a major in Chemical and Biological Engineering and a second major in Biotechnology. Michael plans to pursue graduate studies in toxicology somewhere in Cambridge, MA.