Research/Areas of Interest: reproductive biology and tissue engineering to understand the immune-endocrine mechanisms driving both reproductive physiology and disease pathogenesis.

Education

  • Ph.D. in Cellular and Molecular Pathology, Vanderbilt University Medical Center – Department of Pathology Microbiology and Immunology, United States, 2018
  • B.S. Biotechnology and minors in Biochemistry, Rutgers University – School of Environmental and Biological Sciences, United States, 2018
  • A.S. Mathematics and Sciences: Biology, Raritan Valley Community College, United States, 2010

Biography

Juan S. Gnecco, Ph.D is a Post-doctoral Associate in the Department of Biological Engineering at Massachusetts Institute of Technology (MIT) in the laboratory of Dr. Linda Griffith. He obtained his B.S. in Biotechnology from Rutgers University and PhD in Cellular and Molecular Pathology at Vanderbilt University Medical Center, under the mentorship of Dr. Kevin Osteen. In his PhD thesis, he developed the first microphysiological systems (MPS) model of the perivascular endometrium and deployed this model to illuminate the inflammatory effects exerted by environmental toxicants on the female reproductive tract. At MIT, Dr. Gnecco has led efforts to transform the human clinical relevance of reproductive tract models by defining the interplay between biophysical and biochemical cues on the phenotypes of 3D endometrial cell cultures, using synthetic extracellular matrices to control the cellular microenvironment. In parallel, he initiated and led an effort to define the ex vivo 3D structure and composition of the human endometriotic lesions using tissue clearing and light-sheet imaging approaches. He has been awarded three rounds of funding from Gates Foundation (2018-present) for his work building phenotypic screening models of the female reproductive tract. He has been an invited speaker at the Society for Reproductive Investigation (2020/2021), the Gates Foundation Global Health Integrative Organoid Consortium (2021) and was selected as a Rising Star in Engineering and Health by Columbia University (2020). He serves on the editorial board for Frontiers in Reproductive Health and Experimental Biology and Medicine (EBM) where he received the Outstanding Reviewer award in 2020. Dr. Gnecco's research vision lies at the interface of reproductive biology and tissue engineering to understand the immune-endocrine mechanisms driving both reproductive physiology and disease pathogenesis.