Kyongbum Lee's research interests include metabolic engineering, tissue engineering, and systems biology. His research group is interested in the study of cellular metabolism and its role in directing biological function. The group aims to gain fundamental insights into the biochemical and biophysical cues contributing to the regulation of metabolic pathways, and to develop technologies for assembling, characterizing, and manipulating these systems. It seeks to translate these basic insights and technologies into applications leading to engineering practice and meaningful health outcomes. The group is particularly interested in discovering therapeutic and diagnostic targets for metabolic diseases such as obesity.